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Paclitaxel

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Maxalt

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Rizatriptan

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Rizatriptan benzoate (a derivative of Rizatriptan) is reported as an ingredient of Maxalt in the following countries:

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Glossary

SPC	Summary of Product Characteristics (UK)

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Caelyx

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Topiramate Teva

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Topiramate

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Rifadin syrup 100mg / 5ml

1. Name Of The Medicinal Product

Rifadin Syrup 100mg/5ml

2. Qualitative And Quantitative Composition

Rifampicin Ph Eur 100 mg

3. Pharmaceutical Form

Raspberry coloured and flavoured suspension.

4. Clinical Particulars

4.1 Therapeutic Indications

Indications for use

Tuberculosis: In combination with other active anti-tuberculosis drugs in the treatment of all forms of tuberculosis, including fresh, advanced, chronic and drug-resistant cases. Rifadin is also effective against most atypical strains of Mycobacteria.

Leprosy: In combination with at least one other active anti-leprosy drug in the management of multibacillary and paucibacillary leprosy to effect conversion of the infectious state to a non-infectious state.

Other Infections: In the treatment of Brucellosis, Legionnaires Disease, and serious staphylococcal infections. To prevent emergence of resistant strains of the infecting organisms, Rifadin should be used in combination with another antibiotic appropriate for the infection.

Prophylaxis of meningococcal meningitis: For the treatment of asymptomatic carriers of N. meningitidis to eliminate meningococci from the nasopharynx.

Haemophilus influenzae: For the treatment of asymptomatic carriers of H.influenzae and as chemoprophylaxis of exposed children, 4 years of age or younger.

4.2 Posology And Method Of Administration

Recommended Dosage

For oral administration

The daily dose of Rifadin, calculated from the patient's body weight, should preferably be taken at least 30 minutes before a meal or 2 hours after a meal to ensure rapid and complete absorption.

Tuberculosis:

Rifadin should be given with other effective anti-tuberculosis drugs to prevent the possible emergence of rifampicin-resistant strains of Mycobacteria.

Adults: The recommended single daily dose in tuberculosis is 8-12 mg/kg.

Usual Daily dose: Patients weighing less than 50 kg - 450 mg. Patients weighing 50 kg or more - 600 mg.

Children: In children, oral doses of 10-20 mg/kg body weight daily are recommended, although a total daily dose should not usually exceed 600 mg.

Leprosy:

600 mg doses of rifampicin should be given once per month. Alternatively, a daily regimen may be used. The recommended single daily dose is 10 mg/kg.

Usual daily dose: Patients weighing less than 50 kg - 450 mg. Patients weighing 50 kg or more - 600 mg.

In the treatment of leprosy, rifampicin should always be used in conjunction with at least one other antileprosy drug,

Brucellosis, Legionnaires Disease or serious staphylococcal infections

Adults: The recommended daily dose is 600-1200 mg given in 2 to 4 divided doses, together with another appropriate antibiotic to prevent the emergence of resistant strains of the infecting organisms.

Prophylaxis of meningococcal meningitis

Adults: 600 mg twice daily for 2 days.

Children (1 - 12 years): 10 mg/kg twice daily for 2 days.

Children (3 months - 1 year): 5 mg/kg twice daily for 2 days.

Prophylaxis of Haemophilus influenzae

Adults and children: For members of households exposed to H. influenzae B disease when the household contains a child 4 years of age or younger, it is recommended that all members (including the child) receive rifampicin 20 mg/kg once daily (maximum daily dose 600 mg) for 4 days.

Index cases should be treated prior to discharge from hospital.

Neonates (1 month): 10 mg/kg daily for 4 days.

Impaired liver function:

A daily dose of 8 mg/kg should not be exceeded in patients with impaired liver function.

Use in the elderly:

In elderly patients, the renal excretion of rifampicin is decreased proportionally with physiological decrease of renal function; due to compensatory increase of liver excretion, the terminal half-life in serum is similar to that of younger patients. However, as increased blood levels have been noted in one study of rifampicin in elderly patients, caution should be exercised in using rifampicin in such patients, especially if there is evidence of impaired liver function.

4.3 Contraindications

Rifadin is contra-indicated in the presence of jaundice, and in patients who are hypersensitive to the rifamycins or any of the excipients.

Rifadin use is contraindicated when given concurrently with the combination of saquinavir/ritonavir (see section 4.5 Interactions).

4.4 Special Warnings And Precautions For Use

Rifampicin should be given under the supervision of a respiratory or other suitably qualified physician.

Cautions should be taken in case of renal impairment if dose > 600 mg/day.

All tuberculosis patients should have pre-treatment measurements of liver function.

Adults treated for tuberculosis with rifampicin should have baseline measurements of hepatic enzymes, bilirubin, serum creatinine, a complete blood count, and a platelet count (or estimate).

Baseline tests are unnecessary in children unless a complicating condition is known or clinically suspected.

Patients with impaired liver function should only be given rifampicin in cases of necessity, and then with caution and under close medical supervision. In these patients, lower doses of rifampicin are recommended and careful monitoring of liver function, especially serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) should initially be carried out prior to therapy, weekly for two weeks, then every two weeks for the next six weeks. If signs of hepatocellular damage occur, rifampicin should be withdrawn.

Rifampicin should also be withdrawn if clinically significant changes in hepatic function occur. The need for other forms of antituberculosis therapy and a different regimen should be considered. Urgent advice should be obtained from a specialist in the management of tuberculosis. If rifampicin is re-introduced after liver function has returned to normal, liver function should be monitored daily.

In patients with impaired liver function, elderly patients, malnourished patients, and possibly, children under two years of age, caution is particularly recommended when instituting therapeutic regimens in which isoniazid is to be used concurrently with Rifadin. If the patient has no evidence of pre-existing liver disease and normal pre-treatment liver function, liver function tests need only be repeated if fever, vomiting, jaundice or other deterioration in the patient's condition occur.

Patients should be seen at least monthly during therapy and should be specifically questioned concerning symptoms associated with adverse reactions.

In some patients hyperbilirubinaemia can occur in the early days of treatment. This results from competition between rifampicin and bilirubin for hepatic excretion.

An isolated report showing a moderate rise in bilirubin and/or transaminase level is not in itself an indication for interrupting treatment; rather the decision should be made after repeating the tests, noting trends in the levels and considering them in conjunction with the patient's clinical condition.

Because of the possibility of immunological reaction including anaphylaxis (see section 4.8 Undesirable effects) occurring with intermittent therapy (less than 2 to 3 times per week) patients should be closely monitored. Patients should be cautioned against interrupting treatment.

Rifampicin has enzyme induction properties that can enhance the metabolism of endogenous substrates including adrenal hormones, thyroid hormones and vitamin D. Isolated reports have associated porphyria exacerbation with rifampicin administration.

Rifadin syrup contains sodium metabisulfite which may cause allergic type reactions including anaphylactic symptoms and life threatening or less severe asthmatic episodes in certain susceptible people.

Rifadin syrup may produce reddish coloration of the urine, sweat, sputum and tears, and the patient should be forewarned of this. Soft contact lenses have been permanently stained (see section 4.8).

All patients with abnormalities should have follow up examinations, including laboratory testing, if necessary.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Cytochrome P-450 enzyme interaction

Rifampicin is a potent inducer of certain cytochrome P-450 enzymes. Coadministration of rifampicin with other drugs that are also metabolised through these cytochrome P-450 enzymes may accelerate the metabolism and reduce the activity of these other drugs. Therefore, caution should be used when prescribing rifampicin with drugs metabolised by cytochrome P-450. To maintain optimum therapeutic blood levels, dosages of drugs metabolised by these enzymes may require adjustment when starting or stopping concomitantly administered rifampicin.

Examples of drugs metabolised by cytochrome P-450 enzymes are:

• Antiarrhythmics (e.g. disopyramide, mexiletine, quinidine, propafenone, tocainide),

• Antiepileptics (e.g. phenytoin),

• Hormone antagonist (antiestrogens e.g. tamoxifen, toremifene, gestinone),

• Antipsychotics (e.g. haloperidol, aripiprazole),

• Anticoagulants (e.g. coumarins),

• Antifungals (e.g. fluconazole, itraconazole, ketoconazole, voriconazole),

• Antivirals (e.g. saquinavir, indinavir, efavirenz, amprenavir, nelfinavir, atazanavir, lopinavir, nevirapine),

• Barbiturates

• Beta-blockers (e.g. bisoprolol, propanolol),

• Anxiolytics and hypnotics (e.g. diazepam, benzodiazepines, zolpicolone, zolpidem),

• Calcium channel blockers (e.g. diltiazem, nifedipine, verapamil, nimodipine, isradipine, nicardipine, nisoldipine),

• Antibacterials (e.g. chloramphenicol, clarithromycin, dapsone, doxycycline, fluoroquinolones, telithromycin),

• Corticosteroids

• Cardiac glycosides (digitoxin, digoxin),

• Clofibrate,

• Systemic hormonal contraceptives

• Oestrogen,

• Antidiabetic (e.g. chlorpropamide, tolbutamide, sulfonylureas, rosiglitazone),

• Immunosuppressive agents (e.g. ciclosporin, sirolimus, tacrolimus)

• Irinotecan,

• Thyroid hormone (e.g. levothyroxine),

• Losartan,

• Analgestics (e.g. methadone, narcotic analgesics),

• Praziquantel,

• Progestogens,

• Quinine,

• Riluzole,

• Selective 5-HT3 receptor antagonists (e.g. ondansetron)

• Statins metabolised by CYP 3A4 (e.g. simvastatin),

• Theophylline,

• Tricyclic antidepressants (e.g. amitriptyline, nortriptyline),

• Cytotoxics (e.g. imatinib),

• Diuretics (e.g. eplerenone)

Patients on oral contraceptives should be advised to use alternative, non-hormonal methods of birth control during Rifadin therapy. Also diabetes may become more difficult to control.

Other Interactions

When rifampicin is given concomitantly with the combination saquinavir/ritonavir, the potential for hepatotoxicity is increased. Therefore, concomitant use of Rifadin with saquinvir/ritonavir is contraindicated (see section 4.3 Contraindications).

When the two drugs were taken concomitantly, decreased concentrations of atovaquone and increased concentrations of rifampicin were observed.

Concurrent use of ketoconazole and rifampicin has resulted in decreased serum concentrations of both drugs.

Concurrent use of rifampicin and enalapril has resulted in decreased concentrations of enalaprilat, the active metabolite of enalapril. Dosage adjustments should be made if indicated by the patient's clinical condition.

Concomitant antacid administration may reduce the absorption of rifampicin. Daily doses of rifampicin should be given at least 1 hour before the ingestion of antacids.

When rifampicin is given concomitantly with either halothane or isoniazid, the potential for hepatotoxicity is increased. The concomitant use of rifampicin and halothane should be avoided. Patients receiving both rifampicin and isoniazid should be monitored closely for hepatotoxicity.

If p-aminosalicylic acid and rifampicin are both included in the treatment regimen, they should be given not less than eight hours apart to ensure satisfactory blood levels.

Interference with laboratory and diagnostic tests

Therapeutic levels of rifampicin have been shown to inhibit standard microbiological assays for serum folate and Vitamin B12. Thus alternative assay methods should be considered. Transient elevation of BSP and serum bilirubin has been reported. Rifampicin may impair biliary excretion of contrast media used for visualization of the gallbladder, due to competition for biliary excretion. Therefore, these tests should be performed before the morning dose of rifampicin.

4.6 Pregnancy And Lactation

Pregnancy

At very high doses in animals rifampicin has been shown to have teratogenic effects. There are no well controlled studies with rifampicin in pregnant women. Although rifampicin has been reported to cross the placental barrier and appear in cord blood, the effect of rifampicin, alone or in combination with other antituberculosis drugs, on the human foetus is not known. Therefore, Rifadin should be used in pregnant women or in women of child bearing potential only if the potential benefit justifies the potential risk to the foetus. When Rifadin is administered during the last few weeks of pregnancy it may cause post-natal haemorrhages in the mother and infant for which treatment with Vitamin K1 may be indicated.

Lactation

Rifampicin is excreted in breast milk, patients receiving rifampicin should not breast feed unless in the physician's judgement the potential benefit to the patient outweighs the potential risk to the infant.

4.7 Effects On Ability To Drive And Use Machines

None stated

4.8 Undesirable Effects

Reactions occurring with either daily or intermittent dosage regimens include:

Cutaneous reactions which are mild and self-limiting and do not appear to be hypersensitivity reactions. Typically they consist of flushing and itching with or without a rash. Urticaria and more serious hypersensitivity cutaneous reactions have occurred but are uncommon. Exfoliate dermatitis, pemphigoid reaction, erythema multiforme including Stevens-Johnson syndrome, Lyells syndrome and vasculitis have been reported rarely.

Gastrointestinal reactions consist of anorexia, nausea, vomiting, abdominal discomfort, and diarrhoea. Pseudomembranous colitis has been reported with rifampicin therapy.

Hepatitis can be caused by rifampicin and liver function tests should be monitored (see section 4.4. Special warnings and precautions for use).

Central Nervous System: Psychoses have been rarely reported.

Thrombocytopenia with or without purpura may occur, usually associated with intermittent therapy, but is reversible if drug is discontinued as soon as purpura occurs. Cerebral haemorrhage and fatalities have been reported when rifampicin administration has been continued or resumed after the appearance of purpura.

Disseminated intravascular coagulation has also been rarely reported.

Eosinophilia, leucopenia, oedema, muscle weakness and myopathy have been reported to occur in a small percentage of patients treated with rifampicin.

Agranulocytosis has been reported very rarely reported.

Rare reports of adrenal insufficiency in patients with compromised adrenal function have been observed.

Reactions usually occurring with intermittent dosage regimens and probably of immunological origin include:

- 'Flu Syndrome' consisting of episodes of fever, chills, headache, dizziness, and bone pain appearing most commonly during the 3rd to the 6th monthly of therapy. The frequency of the syndrome varies but may occur in up to 50 % of patients given once-weekly regimens with a dose of rifampicin of 25 mg/kg or more.

- Shortness of breath and wheezing.

- Decrease in blood pressure and shock.

- Anaphylaxis.

- Acute haemolytic anaemia.

- Acute renal failure usually due to acute tubular necrosis or acute interstitial nephritis.

If serious complications arise, e.g. renal failure, thrombocytopenia or haemolytic anaemia, rifampicin should be stopped and never restarted.

Occasional disturbances of the menstrual cycle have been reported in women receiving long-term anti-tuberculosis therapy with regimens containing rifampicin.

Rifampicin may produce a reddish colouration of the urine, sweat, sputum and tears. The patient should be forewarned of this. Soft contact lenses may be permanently stained.

4.9 Overdose

Human Experience

• Signs and Symptoms:

Nausea, vomiting, abdominal pain, pruritus, headache and increasing lethargy will probably occur within a short time after acute ingestion; unconsciousness may occur when there is severe hepatic disease. Transient increases in liver enzymes and/or bilirubin may occur. Brownish-red or orange colouration of the skin, urine, sweat, saliva, tears and faeces will occur, and its intensity is proportional to the amount ingested. Facial or periorbital oedema has also been reported in paediatric patients. Hypotension, sinus tachycardia, ventricular arrhythmias, seizures and cardiac arrest were reported in some fatal cases.

The minimum acute lethal or toxic dose is not well established. However, nonfatal acute overdoses in adults have been reported with doses ranging from 9 to 12 g rifampicin. Fatal acute overdoses in adults have been reported with doses ranging from 14-60 g. Alcohol or a history of alcohol abuse was involved in some of the fatal and nonfatal reports.

Nonfatal overdoses in paediatric patients ages 1 to 4 years old of 100 mg/kg for one to two doses have been reported.

• Management:

Intensive supportive measures should be instituted and individual symptoms treated as they arise. Since nausea and vomiting are likely to be present, gastric lavage is probably preferable to induction of emesis. Following evacuation of the gastric contents, the instillation of activated charcoal slurry into the stomach may help absorb any remaining drug from the gastrointestinal tract. Antiemetic medication may be required to control severe nausea and vomiting. Active diuresis (with measured intake and output) will help promote excretion of the drug. Haemodialysis may be of value in some patients.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Rifampicin is an active bactericidial antituberculosis drug which is particularly active against the rapidly growing extracellular organisms and also has bactericidial activity intracellularly. Rifampicin has activity against slow and intermittently-growing M. Tuberculosis.

Rifampicin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. Cross-resistance to rifampicin has only been shown with other rifamycins.

5.2 Pharmacokinetic Properties

Rifampicin is readily absorbed from the gastrointestinal tract. Peak serum concentrations of the order of 10 µg/ml occur about 2 to 4 hours after a dose of 10 mg/kg body weight on an empty stomach.

Absorption of rifampicin is reduced when the drug is ingested with food.

The pharmacokinetics (oral and intravenous) in children are similar to adults.

In normal subjects the biological half-life of rifampicin in serum averages about 3 hours after a 600 mg dose and increases to 5.1 hours after a 900 mg dose. With repeated administration, the half-life decreases and reaches average values of approximately 2-3 hours. At a dose of up to 600 mg/day, it does not differ in patients with renal failure and consequently, no dosage adjustment is required.

Rifampicin is rapidly eliminated in the bile and an enterophepatic circulation ensues. During this process, rifampicin undergoes progressive deacetylation, so that nearly all the drug in the bile is in this form in about 6 hours. This metabolite retains essentially complete antibacterial activity. Intestinal reabsorption is reduced by deacetylation and elimination is facilitated. Up to 30 % of a dose is excreted in the urine, with about half of this being unchanged drug.

Rifampicin is widely distributed throughout the body. It is present in effective concentrations in many organs and body fluids, including cerebrospinal fluid. Rifampicin is about 80 % protein bound. Most of the unbound fraction is not ionized and therefore is diffused freely in tissues.

5.3 Preclinical Safety Data

Not applicable

6. Pharmaceutical Particulars

6.1 List Of Excipients

Agar	Ph Eur
Sucrose	Ph Eur
Methyl-p-hydroxybenzoate	Ph Eur
Propyl-p-hydroxybenzoate	Ph Eur
Potassium sorbate	Ph Eur
Sodium metabisulphite	Ph Eur
Tween 80	Ph Eur
Raspberry essence	HSE
Saccharin	USNF
Diethanolamine	USNF
Purified water	Ph Eur

6.2 Incompatibilities

None stated

6.3 Shelf Life

3 years from date of manufacture

6.4 Special Precautions For Storage

Store below 30°C.

Do not dilute.

Dispense in clear or amber glass bottles.

6.5 Nature And Contents Of Container

120ml in amber glass bottles

6.6 Special Precautions For Disposal And Other Handling

Not applicable

7. Marketing Authorisation Holder

Sanofi-aventis

One Onslow Street

Guildford

Surrey

GU1 4YS

UK

8. Marketing Authorisation Number(S)

PL 04425/5917R

9. Date Of First Authorisation/Renewal Of The Authorisation

23/03/05

10. Date Of Revision Of The Text

27 October 2011

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Ingredient matches for Clortetrasol

Chlortetracycline

Chlortetracycline is reported as an ingredient of Clortetrasol in the following countries:

• Italy

International Drug Name Search

Meftal

Meftal may be available in the countries listed below.

Ingredient matches for Meftal

Mefenamic Acid

Mefenamic Acid is reported as an ingredient of Meftal in the following countries:

• Sri Lanka

International Drug Name Search

Azilect

In the US, Azilect (rasagiline systemic) is a member of the drug class dopaminergic antiparkinsonism agents and is used to treat Parkinson's Disease.

US matches:

• Azilect

UK matches:

• Azilect 1 mg Tablets
• Azilect 1 mg Tablets (SPC)

Ingredient matches for Azilect

Rasagiline

Rasagiline is reported as an ingredient of Azilect in the following countries:

• Bulgaria


• Russian Federation


• Slovakia

Rasagiline mesilate (a derivative of Rasagiline) is reported as an ingredient of Azilect in the following countries:

• Austria


• Belgium


• Canada


• Croatia (Hrvatska)


• Czech Republic


• Denmark


• Finland


• France


• Germany


• Ireland


• Israel


• Italy


• Luxembourg


• Netherlands


• Norway


• Slovenia


• South Africa


• Spain


• Sweden


• Switzerland


• Turkey


• United Kingdom


• United States

International Drug Name Search

Glossary

SPC	Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

MetroLotion

In the US, MetroLotion (metronidazole topical) is a member of the drug class topical acne agents and is used to treat Perioral Dermatitis and Rosacea.

US matches:

• MetroLotion Cream


• MetroLotion


• Metrolotion Topical

Ingredient matches for MetroLotion

Metronidazole

Metronidazole is reported as an ingredient of MetroLotion in the following countries:

• Canada


• Germany


• United States

International Drug Name Search

Pirantel

Pirantel may be available in the countries listed below.

Ingredient matches for Pirantel

Pyrantel

Pirantel (DCIT) is known as Pyrantel in the US.

International Drug Name Search

Glossary

DCIT	Denominazione Comune Italiana

Click for further information on drug naming conventions and International Nonproprietary Names.

Remark

Remark may be available in the countries listed below.

Ingredient matches for Remark

Betahistine

Betahistine dimesilate (a derivative of Betahistine) is reported as an ingredient of Remark in the following countries:

• Japan

International Drug Name Search

Pranox

Pranox may be available in the countries listed below.

Ingredient matches for Pranox

Pranoprofen

Pranoprofen is reported as an ingredient of Pranox in the following countries:

• Belgium


• Luxembourg

International Drug Name Search

Lovatrol

Lovatrol may be available in the countries listed below.

Ingredient matches for Lovatrol

Lovastatin

Lovastatin is reported as an ingredient of Lovatrol in the following countries:

• Indonesia

International Drug Name Search

Amantadine Quality Pharm

Amantadine Quality Pharm may be available in the countries listed below.

Ingredient matches for Amantadine Quality Pharm

Amantadine

Amantadine hydrochloride (a derivative of Amantadine) is reported as an ingredient of Amantadine Quality Pharm in the following countries:

• Hong Kong

International Drug Name Search

Ratio-Oxycodan

ratio-Oxycodan may be available in the countries listed below.

Ingredient matches for ratio-Oxycodan

Aspirin

Acetylsalicylic Acid is reported as an ingredient of ratio-Oxycodan in the following countries:

• Canada

Oxycodone

Oxycodone hydrochloride (a derivative of Oxycodone) is reported as an ingredient of ratio-Oxycodan in the following countries:

• Canada

International Drug Name Search

Feprorex

Feprorex may be available in the countries listed below.

Ingredient matches for Feprorex

Fenproporex

Fenproporex hydrochloride (a derivative of Fenproporex) is reported as an ingredient of Feprorex in the following countries:

• Mexico

International Drug Name Search

Tocorell Vit. E

Tocorell Vit. E may be available in the countries listed below.

Ingredient matches for Tocorell Vit. E

Tocopherol, α-

Tocopherol, α- is reported as an ingredient of Tocorell Vit. E in the following countries:

• Germany

International Drug Name Search

Chlorphenamine Maleate

Chlorphenamine Maleate may be available in the countries listed below.

Ingredient matches for Chlorphenamine Maleate

Chlorphenamine

Chlorphenamine Maleate (BANM) is also known as Chlorphenamine (Rec.INN)

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Clavulin Junior

Clavulin Junior may be available in the countries listed below.

Ingredient matches for Clavulin Junior

Amoxicillin

Amoxicillin is reported as an ingredient of Clavulin Junior in the following countries:

• Colombia

Clavulanate

Clavulanic Acid is reported as an ingredient of Clavulin Junior in the following countries:

• Colombia

International Drug Name Search

Rantac

Rantac may be available in the countries listed below.

Ingredient matches for Rantac

Ranitidine

Ranitidine is reported as an ingredient of Rantac in the following countries:

• Ethiopia


• Sri Lanka

Ranitidine hydrochloride (a derivative of Ranitidine) is reported as an ingredient of Rantac in the following countries:

• India


• Oman


• Russian Federation


• Thailand

International Drug Name Search

Gasdol

Gasdol may be available in the countries listed below.

Ingredient matches for Gasdol

Domperidone

Domperidone is reported as an ingredient of Gasdol in the following countries:

• Chile

International Drug Name Search

Renolip

Renolip may be available in the countries listed below.

Ingredient matches for Renolip

Gemfibrozil

Gemfibrozil is reported as an ingredient of Renolip in the following countries:

• Greece

International Drug Name Search

Rapril

Rapril may be available in the countries listed below.

Ingredient matches for Rapril

Ramipril

Ramipril is reported as an ingredient of Rapril in the following countries:

• Tunisia

International Drug Name Search

Metronidazole Teva

Metronidazole Teva may be available in the countries listed below.

Ingredient matches for Metronidazole Teva

Metronidazole

Metronidazole is reported as an ingredient of Metronidazole Teva in the following countries:

• Latvia

International Drug Name Search

International Apex Tenoxicam

International Apex Tenoxicam may be available in the countries listed below.

Ingredient matches for International Apex Tenoxicam

Tenoxicam

Tenoxicam is reported as an ingredient of International Apex Tenoxicam in the following countries:

• Philippines

International Drug Name Search

Losartan Winthrop Lab

Losartan Winthrop Lab may be available in the countries listed below.

Ingredient matches for Losartan Winthrop Lab

Losartan

Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Losartan Winthrop Lab in the following countries:

• France

International Drug Name Search

Amsaxilina

Amsaxilina may be available in the countries listed below.

Ingredient matches for Amsaxilina

Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amsaxilina in the following countries:

• Mexico

International Drug Name Search

Palistop

Palistop may be available in the countries listed below.

Ingredient matches for Palistop

Flutamide

Flutamide is reported as an ingredient of Palistop in the following countries:

• Greece

International Drug Name Search

Gino-Lotremine

Gino-Lotremine may be available in the countries listed below.

Ingredient matches for Gino-Lotremine

Clotrimazole

Clotrimazole is reported as an ingredient of Gino-Lotremine in the following countries:

• Portugal

International Drug Name Search

Cincelakin

Cincelakin may be available in the countries listed below.

Ingredient matches for Cincelakin

Ambroxol

Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Cincelakin in the following countries:

• Japan

International Drug Name Search

Betacar

Betacar may be available in the countries listed below.

Ingredient matches for Betacar

Atenolol

Atenolol is reported as an ingredient of Betacar in the following countries:

• Chile

Carvedilol

Carvedilol is reported as an ingredient of Betacar in the following countries:

• Peru

International Drug Name Search

Pelimed Schmerz extra

Pelimed Schmerz extra may be available in the countries listed below.

Ingredient matches for Pelimed Schmerz extra

Ibuprofen

Ibuprofen is reported as an ingredient of Pelimed Schmerz extra in the following countries:

• Germany

International Drug Name Search

Tromlipon

Tromlipon may be available in the countries listed below.

Ingredient matches for Tromlipon

Thioctic Acid

Thioctic Acid is reported as an ingredient of Tromlipon in the following countries:

• Germany

Thioctic Acid tromethamine (a derivative of Thioctic Acid) is reported as an ingredient of Tromlipon in the following countries:

• Germany

International Drug Name Search

Fluoxetin 1A Farma

Fluoxetin 1A Farma may be available in the countries listed below.

Ingredient matches for Fluoxetin 1A Farma

Fluoxetine

Fluoxetine hydrochloride (a derivative of Fluoxetine) is reported as an ingredient of Fluoxetin 1A Farma in the following countries:

• Denmark

International Drug Name Search

Prazosin-ratiopharm

Prazosin-ratiopharm may be available in the countries listed below.

Ingredient matches for Prazosin-ratiopharm

Prazosin

Prazosin hydrochloride (a derivative of Prazosin) is reported as an ingredient of Prazosin-ratiopharm in the following countries:

• Germany

International Drug Name Search

Medroxoral

Medroxoral may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Medroxoral

Medroxyprogesterone

Medroxyprogesterone 17α-acetate (a derivative of Medroxyprogesterone) is reported as an ingredient of Medroxoral in the following countries:

• Netherlands

International Drug Name Search

Ceferro

Ceferro may be available in the countries listed below.

Ingredient matches for Ceferro

Ferrous Sulfate

Ferrous Sulfate is reported as an ingredient of Ceferro in the following countries:

• Germany

International Drug Name Search

Rodisec

Rodisec may be available in the countries listed below.

Ingredient matches for Rodisec

Omeprazole

Omeprazole is reported as an ingredient of Rodisec in the following countries:

• Belize


• El Salvador


• Guatemala


• Honduras


• Nicaragua

International Drug Name Search

Myorelax

Myorelax may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Myorelax

Guaifenesin

Guaifenesin is reported as an ingredient of Myorelax in the following countries:

• Belgium

Mephenesin

Mephenesin is reported as an ingredient of Myorelax in the following countries:

• Tunisia

International Drug Name Search

Benestan

Benestan may be available in the countries listed below.

Ingredient matches for Benestan

Alfuzosin

Alfuzosin hydrochloride (a derivative of Alfuzosin) is reported as an ingredient of Benestan in the following countries:

• Portugal


• Spain

International Drug Name Search

Cleveron

Cleveron may be available in the countries listed below.

Ingredient matches for Cleveron

Alendronic Acid

Alendronic Acid sodium trihydrate (a derivative of Alendronic Acid) is reported as an ingredient of Cleveron in the following countries:

• Brazil

International Drug Name Search

Algopress

Algopress may be available in the countries listed below.

Ingredient matches for Algopress

Mefenamic Acid

Mefenamic Acid is reported as an ingredient of Algopress in the following countries:

• Greece

International Drug Name Search

Acido Acetilsalicilico + Vitamina C Mylan

Acido Acetilsalicilico + Vitamina C Mylan may be available in the countries listed below.

Ingredient matches for Acido Acetilsalicilico + Vitamina C Mylan

Aspirin

Acetylsalicylic Acid is reported as an ingredient of Acido Acetilsalicilico + Vitamina C Mylan in the following countries:

• Italy

Ascorbic Acid

Ascorbic Acid is reported as an ingredient of Acido Acetilsalicilico + Vitamina C Mylan in the following countries:

• Italy

International Drug Name Search

Maygace Altas Dosis

Maygace Altas Dosis may be available in the countries listed below.

Ingredient matches for Maygace Altas Dosis

Megestrol

Megestrol 17α-acetate (a derivative of Megestrol) is reported as an ingredient of Maygace Altas Dosis in the following countries:

• Spain

International Drug Name Search

Rispéridone Winthrop

Rispéridone Winthrop may be available in the countries listed below.

Ingredient matches for Rispéridone Winthrop

Risperidone

Risperidone is reported as an ingredient of Rispéridone Winthrop in the following countries:

• France

International Drug Name Search

Ciprofloxacino Diasa

Ciprofloxacino Diasa may be available in the countries listed below.

Ingredient matches for Ciprofloxacino Diasa

Ciprofloxacin

Ciprofloxacin lactate (a derivative of Ciprofloxacin) is reported as an ingredient of Ciprofloxacino Diasa in the following countries:

• Spain

International Drug Name Search

Irinotecan Mylan

Irinotecan Mylan may be available in the countries listed below.

Ingredient matches for Irinotecan Mylan

Irinotecan

Irinotecan hydrochloride trihydrate (a derivative of Irinotecan) is reported as an ingredient of Irinotecan Mylan in the following countries:

• Slovakia

International Drug Name Search

Calpo

Calpo may be available in the countries listed below.

Ingredient matches for Calpo

Calcium Carbonate

Calcium Carbonate is reported as an ingredient of Calpo in the following countries:

• Bangladesh

International Drug Name Search

Magium 5 / 10 Brause

Magium 5/10 Brause may be available in the countries listed below.

Ingredient matches for Magium 5/10 Brause

Magnesium Oxide

Magnesium Oxide light (a derivative of Magnesium Oxide) is reported as an ingredient of Magium 5/10 Brause in the following countries:

• Germany

International Drug Name Search

Cefalexim

Cefalexim may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Cefalexim

Cefalexin

Cefalexin is reported as an ingredient of Cefalexim in the following countries:

• Poland

International Drug Name Search

Equimec

Equimec may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Equimec

Ivermectin

Ivermectin is reported as an ingredient of Equimec in the following countries:

• Australia

International Drug Name Search

Losagen

Losagen may be available in the countries listed below.

Ingredient matches for Losagen

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Losagen in the following countries:

• Slovakia

Losartan

Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Losagen in the following countries:

• Slovakia

International Drug Name Search

Famohexal

Famohexal may be available in the countries listed below.

Ingredient matches for Famohexal

Famotidine

Famotidine is reported as an ingredient of Famohexal in the following countries:

• Australia


• Austria

International Drug Name Search

Blustark

Blustark may be available in the countries listed below.

Ingredient matches for Blustark

Ferrous Gluconate

Ferrous Gluconate is reported as an ingredient of Blustark in the following countries:

• Italy

International Drug Name Search

Encephabol

Encephabol may be available in the countries listed below.

Ingredient matches for Encephabol

Pyritinol

Pyritinol is reported as an ingredient of Encephabol in the following countries:

• Austria


• Luxembourg


• Mexico

Pyritinol dihydrochloride (a derivative of Pyritinol) is reported as an ingredient of Encephabol in the following countries:

• Austria


• Bahrain


• Cyprus


• Czech Republic


• Egypt


• Georgia


• Germany


• Hong Kong


• India


• Indonesia


• Iran


• Iraq


• Jordan


• Kuwait


• Latvia


• Lebanon


• Luxembourg


• Mexico


• Oman


• Philippines


• Qatar


• Romania


• Russian Federation


• Saudi Arabia


• South Africa


• Sudan


• Thailand


• United Arab Emirates


• Yemen

International Drug Name Search

Atemperator

Atemperator may be available in the countries listed below.

Ingredient matches for Atemperator

Bromazepam

Bromazepam is reported as an ingredient of Atemperator in the following countries:

• Argentina

Valproic Acid

Valproic Acid is reported as an ingredient of Atemperator in the following countries:

• Chile

Valproic Acid magnesium (a derivative of Valproic Acid) is reported as an ingredient of Atemperator in the following countries:

• Colombia


• Costa Rica


• Dominican Republic


• El Salvador


• Guatemala


• Mexico


• Nicaragua

Valproic Acid sodium (a derivative of Valproic Acid) is reported as an ingredient of Atemperator in the following countries:

• Ecuador

International Drug Name Search

Brofex

Brofex may be available in the countries listed below.

Ingredient matches for Brofex

Dextromethorphan

Dextromethorphan hydrobromide (a derivative of Dextromethorphan) is reported as an ingredient of Brofex in the following countries:

• Bangladesh

International Drug Name Search

Azelex

In the US, Azelex (azelaic acid topical) is a member of the drug class topical acne agents and is used to treat Acne and Rosacea.

US matches:

• Azelex Cream


• Azelex


• Azelex Topical

Ingredient matches for Azelex

Azelaic Acid

Azelaic Acid is reported as an ingredient of Azelex in the following countries:

• United States

International Drug Name Search

Caleobrol

Caleobrol may be available in the countries listed below.

Ingredient matches for Caleobrol

Calcitriol

Calcitriol is reported as an ingredient of Caleobrol in the following countries:

• Chile

International Drug Name Search

Colopriv

Colopriv may be available in the countries listed below.

Ingredient matches for Colopriv

Mebeverine

Mebeverine is reported as an ingredient of Colopriv in the following countries:

• Tunisia

Mebeverine hydrochloride (a derivative of Mebeverine) is reported as an ingredient of Colopriv in the following countries:

• Algeria


• France

International Drug Name Search

Efrotomycin

In some countries, this medicine may only be approved for veterinary use.

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0056592-32-6

Chemical Formula

C59-H88-N2-O20

Molecular Weight

1145

Therapeutic Category

Growth stimulant

Chemical Names

(αS,2R,3R,4R,6S)-4-[[6-Deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-L-mannopyranosyl)-3-O-methyl-ß-D-allopyranosyl]oxy]-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-5-[(1E,3E,5E)-6-(1,2-dihydro-4-hydroxy-1-methyl-2-oxonicotinoyl)-1,3,5-heptatrienyl]-α-ethyltetrahydro-2,3-di (WHO)

An antibacterial produced by Streptomyces lactamduransand comprising three components: efrotomycin A₁, efrotomycin A₂ (an isomer of A₁) and efrotomycin B (BAN)

Mocimycin, 31-O-[6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-L-mannopyranosyl)-3-O-methyl-ß-D-allopyranosyl]-1-methyl- (USAN)

Foreign Names

• Efrotomycinum (Latin)
• Efrotomycin (German)
• Éfrotomycine (French)
• Efrotomicina (Spanish)

Generic Names

• Efrotomycin (OS: BAN, USAN)
• Antibiotic FR 02A (IS)
• BRN 5230192 (IS)
• FR-02A (IS)
• L 682313-000 (IS)
• MK-621 (IS: Merck)

Brand Name

• Producil (veterinary use)
  Merial, United States

International Drug Name Search

Glossary

BAN	British Approved Name
IS	Inofficial Synonym
OS	Official Synonym
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Feosol

In the US, Feosol (ferrous sulfate systemic) is a member of the drug class iron products and is used to treat Anemia Associated with Chronic Renal Failure, Iron Deficiency Anemia, Vitamin/Mineral Supplementation and Deficiency and Vitamin/Mineral Supplementation during Pregnancy/Lactation.

US matches:

• FeoSol


• Feosol Caplet

Ingredient matches for Feosol

Ferrous Sulfate

Ferrous Sulfate is reported as an ingredient of Feosol in the following countries:

• Philippines


• United States

Iron Dextran

Iron Dextran is reported as an ingredient of Feosol in the following countries:

• United States

International Drug Name Search

Buclizine Hydrochloride

Buclizine Hydrochloride may be available in the countries listed below.

Ingredient matches for Buclizine Hydrochloride

Buclizine

Buclizine Hydrochloride (BANM, USAN) is also known as Buclizine (Rec.INN)

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Rolid

Rolid may be available in the countries listed below.

Ingredient matches for Rolid

Roxithromycin

Roxithromycin is reported as an ingredient of Rolid in the following countries:

• Bangladesh

International Drug Name Search

Amikayect

Amikayect may be available in the countries listed below.

Ingredient matches for Amikayect

Amikacin

Amikacin sulfate (a derivative of Amikacin) is reported as an ingredient of Amikayect in the following countries:

• Mexico

International Drug Name Search